Cancer is a generic term for a group of diseases which can affect any body organ or system characterized by rapid, uncontrollable and abnormal cell growth and division, as well as the ability to spread throughout the body (metastasis). The cancer is usually named after the organ where it started from, for example lung cancer whereas metastasis from another organ to the lungs is not lung cancer, but cancer of the organ of origin that has spread to the lungs.
Lung cancer is the most common cause of death from cancers in Greece.1
Causes of Lung Cancer
Tobacco smoke through both active and passive smoking is responsible for more than 80% of all lung cancer cases indicating it is a highly preventable disease. A much smaller percentage of cases are attributed to occupational and environmental exposures to known carcinogenic factors such as asbestos, radiation, radon, beryllium, chromium, diesel exhaust and arsenic. 2
An important characteristic of lung cancer is that it develops slowly over time usually taking up to two decades for signs and symptoms to appear (time-lag effect).
In reality, the negative health effects begin from the first cigarette and cumulatively add-up over time (dose and duration-dependent). That’s why physicians ask about the number of cigarettes smoked per day and years of smoking so they can calculate number of pack-years (PY).
- PY= number of packages smoked per day multiplied by years of smoking
Symptoms of lung cancer are relatively vague and vary by each person. Many times symptoms do not present until the cancer has spread to the rest of the body. Some of the symptoms can include:3
- Coughing that progressively worsens and persists
- Chest pain
- Shortness of Breath
- Coughing up blood
- Feeling tired
- Excessive unexplained weight loss
- Clubbing of fingernails (when the tip of the finger is enlarged and appears like the round part of an upside-down spoon)
Diagnosis and Treatment4
Lung cancer has several histological types. Prognosis is different for each case depending on several factors, most importantly, the histological type and disease stage at the time of diagnosis. In clinical practice the main lung cancer differentiations are small cell and non-small cell lung cancer, requiring different therapeutic approaches.
Treatment options include surgery, chemotherapy and radiotherapy. Recent advances in chemotherapy (immunotherapy, molecular, targeted or precision therapy), in surgery (minimal invasion and video-assisted procedures) and in diagnosing and staging (CT scan, PET scan, endoscopic ultrasound) have led to early diagnosis, improved prognosis and quality of life.
Lung cancer caused by tobacco smoke is completely preventable through tobacco smoking prevention and cessation. There is no safe limit for smoking or passive smoking. It is highly recommended to avoid smoking and second-hand smoke in order to prevent ever occurrence of lung cancer.
Since smokers are considered a high risk population for lung cancer, the Hellenic Thoracic Society but also European and American Respiratory Societies recommend:
- An annual low-dose chest CT-scan for early diagnosis at a treatable stage to:
- all smokers over 55 years old and/or
- people with >20 pack years (even if they are younger than 50).
What’s Happening in Greece?
In Greece, lung, trachea and bronchus cancers account for the 3rd overall cause of death in the country.1
Lung cancer is the 1st cause, accounting for 31%, of cancer deaths among men in Greece, while in women it is the 3rd cause and accounts for 10%, respectively. However, this proportion in women is expected to increase in the future due to increased smoking prevalence among women in recent years.1
The Good News: Smoking is decreasing among youth in Greece!
Smoking prevalence has been steadily declining in Greece since 2009 especially among ages 16-24 years, old who have showed a 33% reduction in smoking prevalence from 2009 to 2014.5 This reduction supports the expectation of a reduction in lung cancer cases due to a younger generation which chooses not to smoke!
Read the Greek version, here.
- International Agency for Research on Cancer. GLOBOCAN 2012: Estimated Cancer Incidence, Mortality, and Prevalence Worldwide in 2012, Population Fact Sheet: Greece. http://globocan.iarc.fr/Pages/fact_sheets_population.aspx. Published 2012.
- European Lung Foundation. Lung cancer. http://www.europeanlung.org/en/lung-disease-and-information/lung-diseases/lung-cancer.
- US. Center of Disease Control and Prevention. CDC – What Are the Symptoms of Lung Cancer? https://www.cdc.gov/cancer/lung/basic_info/symptoms.htm. Published 2013.
- National Cancer Institute. Treatment for Cancer – National Cancer Institute. https://www.cancer.gov/about-cancer/treatment. Published 2015.
- Demi M, Teloniatis S, Vyzikidou V-K, et al. Smoking Prevalence in Greece. Tob Prev Cessat. 2018;4(Supplement). doi:10.18332/tpc/90109.
By Anna Tzortzi, MD, Pulmonologist
Scientific Director “George D. Behrakis Research Lab”
Associate Director “Institute of Public Health, The American College of Greece”
and Stephanie Teloniatis, Editing & Technical Support